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Clinical Results


Alchimie Forever's concept

Alchimie Forever products are the result of over 20 years of clinical experience in the fields of skin aging and scientific research specific to antioxidants.

To combat skin aging and preserve the radiance of young skin, Alchimie Forever products, for face and body, combine the most powerful natural antioxidants, such as flavonoids, vitamins, iron chelators, and inducers of stress proteins. These natural antioxidants, herbal extracts (rosemary, basil), plants (green tea, turmeric) and fruits (blueberries, grape seed, tomatoes) have complementary effects that protect the skin while making it healthier and younger.

We control the entire production chain: from concept to the selection of ingredients, the formulation for the production, the analysis, the quality controls, the packaging, and the clinical studies. Our products are stable, hypoallergenic and ideal for sensitive skin. They contain no animal products; they are not tested on animals and are perfectly suitable for vegan use.

The scientific integrity has always been a central value for Alchimie Forever. Our scientific team, who is at the heart of the product development and selection of ingredients, publish continuously in specialized journals articles on skin, antioxidants, and cosmetic ingredients.


Antioxidants are used in the prevention and treatment of skin aging. Oxygen, which is essential to our aerobic life, is metabolized in the body by successive reductions resulting in oxidants or free radicals. These oxidants play, in low concentration, important roles in cellular signaling, activation, and differentiation. In slightly higher concentrations, oxidants play a role in protection against infection. But the production of oxidants must be controlled so as not to be deleterious to the organism itself that produces them.

Upon exposure to UV rays, massive amounts of oxidants are produced in the skin. They lead to immediate and lasting changes such as skin laxity, wrinkles, and brown spots.

Chemical or physical screens today play a vital role in protection against UV rays. Even with the proper use of the best screens, some UV penetrates into the skin and creates excessive oxidant production: it is here that antioxidants play a role.

Antioxidants derived from plants, or phytoantioxydants, are very active molecules against skin aging. Plants are like us, likely to suffer from excessive production of oxidants generated by UV. But unlike us, they cannot move into the shade, wear clothes, or use sunscreen... they have therefore developed highly effective strategies in terms of antioxidants. This is why we find, in plants, the most potent antioxidants and the best antioxidant combinations that can protect cells against skin aging caused by UV.

The majority of phytoantioxydants are polyphenols which include a large family of molecules which are the flavonoids, carotenoids, anthocyanins,....

Iron Chelators

As oxygen, iron is essential for life and aerobic energy production. But similar to oxygen, it can be toxic. Not all irons are toxic, just those that are no longer protected by an envelope, called free iron. This iron increases the production of free radicals and plays an aggravating role in aging. In the skin, the UV rays displace the iron from its protective envelope and it becomes free iron which contributes to the direct toxicity of antioxidants in the skin. Iron levels are consistently higher in skin exposed to UV light (forehead, cheeks) than in unexposed areas (buttocks, thighs).

Chelation of free iron in the skin prevents and inhibits the production of oxidants.The word chelation comes from “chele”, which is Greek for “claw.” When the iron is chelated, it is encompassed as if in a “claw-like complex” and thus unable to produce oxidants.

Natural iron chelators, such as quercetin, a flavonoid found in many fruits and plants like blueberries, grapes and green tea, prevent free iron from inducing our skin cells to produce oxidants. Quercetin is anti-aging molecule for our skin.

Stress (Heat Shock) Proteins

While excessive stress can be harmful to the psyche and the body, occasional manageable stress can be positive by encouraging the optimization of the body’s biological response- putting us into survival mode and contributing to our resilience.

This positive response to stress is due to the existence of stress proteins also known as heat shock proteins, whose production is induced when the body is exposed to stress (here, think of stress not as a looming deadline approaching, but rather heat or infection). These proteins should really be called “anti-stress proteins” as their role is to act against the effects of stress. Stress proteins are powerful protectors, as they have the ability to prevent damage to the organism from stresses such as overheating or oxidation induced by exposure to free radicals.

An interesting question is to wonder if it is possible to induce these protective stress proteins when the cell itself is not stressed- activating the positive protective mechanisms in the absence of stress. While pharmacological research on this topic is ongoing, several plant extracts such as turmeric have been identified to have such properties. Turmeric (extracted from Curcuma longa) is found in curry spice mixtures and used in many Indian and Middle Eastern dishes. Most interestingly, curcumin is indeed a non-stressful inducer of stress proteins – i.e., it increases the levels of stress protection by yet unknown mechanisms that do not depend on the presence of actual cellular stress. Curcumin protects your skin against stress!

Clinical studies

Alchimie Forever conducted two clinical studies on the immediate firming effect of age defying serums and firming gel for neck and bust with the Proclaim Laboratory in France.

Each product was applied on dry skin at 2μl per cm2 on a 25 cm2 zone on the forearm. Each volunteer was her own control. Evaluations were conducted after 3 minutes, 1 hour and 2 hours. The results were quantified using an elastometer which measures skin firmness according to a method of suction (quantitative methodology).

The rate of skin firmness of the area treated with the age defying serums increased significantly by 20.4% after 3 minutes of application and 10.2% after one hour and two hours.

The rate of skin firmness of the area treated with the firming gel for neck and bust increased significantly by 10% on average after 3 minutes, one hour and two hours.

Read more about clinical results on our Firming gel for neck and bust here.

In conclusion, the age defying serums and firming gel for neck and bust have a clinically proven, immediate, tightening effect of the upper layers of the epidermis.