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Advanced retinol serum with time release technology

16 reviews

Advanced retinol serum with time release technology

16 reviews


Looking to reduce the appearance of fine lines and wrinkles? Retinol is the gold standard in any anti-aging skin care regimen, and this powerful retinol serum has you covered, with a 0.75% pure retinol concentration.

The proprietary time-release technology minimizes irritation, while our signature ingredient, the European blueberry, in synergy with hydrating hyaluronic acid, jojoba, and collagen-boosting red clover, calms the skin and helps to minimize side effects typically associated with retinol.

A cocktail of powerful antioxidants including apple stem cell extract, edelweiss, and green tea, further enhances the skin's youthful appearance and defends against signs of aging caused by the sun.

  • 1 oz

    Visibly reduces the appearance of fine lines and wrinkles

    Visibly reduces the appearance of age spots


    Anti-aging benefits

  • Apply a pea-sized amount in the evening to clean, dry skin, on face and neck, avoiding the eye area, once or twice per week. Follow with a moisturizer if desired. For sensitive skin, begin using once per week to allow skin to acclimate and gradually work up to recommended frequency of use. Protect your results by wearing sunscreen daily.


    Flaking and redness may be possible. Do not use this product if you are nursing or pregnant. Avoid facial waxing for 72 hours pre and post application.


    0.75% retinol (pure retinol and retinol in time-release technology), hyaluronic acid, vitamin C, vitamin E, green tea (catechin, quercetin, epicatechin), European blueberry (anthocyans, quercetin, resveratrol), edelweiss, red clover (isoflavone), apple (phloretin), jojoba.


    Water/Aqua, Caprylic/Capric Triglyceride, Isononyl Isononanoate, Glycerin, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Allyl Methacrylates Crosspolymer, Squalane, Simmondsia Chinensis (Jojoba) Seed Oil, Retinol, Camellia Sinensis (Green Tea) Leaf Extract, Vaccinium Myrtillus (Bilberry) Fruit Extract, Leontopodium Alpinum (Edelweiss) Extract, Trifolium Pratense (Clover) Flower Extract, Malus Domestica Fruit Cell Culture Extract, Sodium Hyaluronate, Ascorbyl Glucoside, Tocopherol, Polysorbate 20, Polysorbate 60, Sodium Hydroxide, Sodium Metabisulfite, Isomalt, Disodium EDTA, Chlorphenesin, Benzyl Alcohol, Benzoic Acid, Sorbic Acid, Fragrance/Parfum, Geraniol, Hexyl Cinnamal, Alpha Isomethyl Ionone, Amyl Cinnamal, Linalool, Butylphenyl Methylpropional, Citronellol, Limonene.

    Visit our Full Ingredient List and Definition page to learn more about our ingredients. 


    Parabens, sulfates, mineral oil, silicones, propylene glycol, ethoxylated ingredients (PEGs), phenoxyethanol, gluten, dyes, phthalates, genetically-modified organisms (GMOs), formaldehyde and formaldehyde releasers, soy, nuts, animal testing, animal byproducts.

  • Learn more about our New! Advanced Retinol Serum.


  • Our Recent Press:

Clean formulations, clinical results. Dermatologist-formulated and tested. Paraben-free, gluten-free, cruelty-free and vegan.

Customer Reviews
4.7 Based on 16 Reviews
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Filter Reviews:
Catherine D.
United States United States
Loving it so far

As an ardent (daily) exfoliator who has never used retinol I thought it best to back off on the exfoliation and slowly add the retinol into my skincare regime. So far so good! I have gradually increased usage to twice a week with no breakouts, flakiness, scaling or irritation so I'd call that a good response. This week I plan to increase to three times per week and I hope for the best. I'll report back soon but as a first retinol experience I am more than pleased. If you are hesitant to try retinol I'd say 'give this product a go'!

Isabelle G.
Canada Canada

Great product! A light texture, non-greasy with a delicate odor. Good for sensitive skin.

Catherine H.
United States United States
Best ever

This retinol is stellar! I started using it October 2019 and it’s amazing the difference in my skin!! I will not live without this product. Thank You Alchimie

Shery E.
United States United States
Retinol Serum

I wasn't expecting much from a retinol product with 0.75% retinol, as I have previously used 1% and 5% products. I have been so pleasantly surprised with this product as I can see the results, but have had no side effects overall. I would definitely recommend this retinol serum to anyone who has sensitive skin, and didn't want to risk side effects from retinol, but wanted the benefit.

Alissa H.
United States United States
Love it!

Really gentle yet effective.

United States United States
Advanced retinol serum

So far this has been great. my skin definitely broke out in the beginning as my skin was purging all the toxins but after 2 weeks the acne cleared up and my skin is now extremely clear. Excited to see how it will continue to improve

Catherine H.
United States United States
Best Retinol on the Market

If you are shopping for a retinol, look no further. Alchimie's 48-hour time release formula delivers a punch without irritating my skin. It's quite astonishing. The consistency and scent are great ... but can we talk about the results? When your aesthetician notices a difference in the firmness of your skin and the reduction of wrinkles, you know you landed on a stellar product!

Térence M.
Switzerland Switzerland

See results quickly

Christine v.
Switzerland Switzerland
Advanced Retinol 0.75 Serum with time release technology

Used that serum once a week / ( tried twice a week, but the skin reaction was too strong ! ) < The RESULT is better than the one obtained with "Fraxel Laser Dual" as far as the surface of the skin is concerned. < Fraxel Laser Dual acts more deeply in the dermal tissues but its results are far less noticeable on the skin surface ( wrinkles ) smoothness of the skin, glow. < I'm puzzled by Advanced Retinol 0.75% Serum effects. / ..... didn't start with retinol 0.2, 0.3, 0.5 and haven't tried Retinol 1.0 Thank you Alchimie-Forever

Christine V.
Switzerland Switzerland
on try / i think i'm NOT capable of rating as the product is still on try

If i use Advanced Retinol Serum 0.75 once a week, skin reaction is unnoticeable. Tried twice a week... the effect is noticeably stronger in terms of flaking and redness... retinol is powerful. Before this try, used Mene & Moy AHA 30% Advanced C cream daily and it worked perfectly, but i started AHA with Neostrata 15% AHA for quite a while. Dr. Leonardo Luigi Polla gave me that advice. After years of Neostrata started with Mene & Moy 30%. Tried both retinol 0.75 & AHA 30%... skin reaction was powerful... Tried Vitamin C 15% after Retinol twice a week ... the reaction was amazing in terms of redness... / to Sum it all up, customers must try and choose the best for their skin... or turn towards Skinceuticals Custom dose... / i didn't try yet. I think customers MUST try and choose, they're have their part of responsability : )))) !!!! / video :