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Clean formulations. Clinical results.

Advanced retinol serum with time-release technology

19 reviews

Looking to reduce the appearance of fine lines and wrinkles? Retinol is the gold standard in any anti-aging skin care regimen, and this powerful retinol serum has you covered, with a 0.75% pure retinol concentration.

The proprietary time-release technology minimizes irritation, while our signature ingredient, the European blueberry, in synergy with hydrating hyaluronic acid, jojoba, and collagen-boosting red clover, calms the skin and helps to minimize side effects typically associated with retinol.

A cocktail of powerful antioxidants including apple stem cell extract, edelweiss, and green tea, further enhances the skin's youthful appearance and defends against signs of aging caused by the sun.

  • 1 oz.

    Visibly reduces the appearance of fine lines and wrinkles.

    Visibly reduces the appearance of age spots.


    Anti-aging benefits.

  • Apply a pea-sized amount in the evening to clean, dry skin, on face and neck, avoiding the eye area, once or twice per week. Follow with a moisturizer if desired. For sensitive skin, begin using once per week to allow skin to acclimate and gradually work up to recommended frequency of use. Protect your results by wearing sunscreen daily.


    Flaking and redness may be possible. Do not use this product if you are nursing or pregnant. Avoid facial waxing for 72 hours pre and post application.


    European blueberry (anthocyans, quercetin, resveratrol), green tea (catechin, quercetin, epicatechin), red clover (isoflavone), apple (stem cells), edelweiss (leontopodic acid), jojoba.


    Water/Aqua, Caprylic/Capric Triglyceride, Isononyl Isononanoate, Glycerin, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Allyl Methacrylates Crosspolymer, Squalane, Simmondsia Chinensis (Jojoba) Seed Oil, Retinol, Camellia Sinensis (Green Tea) Leaf Extract, Vaccinium Myrtillus (Bilberry) Fruit Extract, Leontopodium Alpinum (Edelweiss) Extract, Trifolium Pratense (Clover) Flower Extract, Malus Domestica Fruit Cell Culture Extract, Sodium Hyaluronate, Ascorbyl Glucoside, Tocopherol, Polysorbate 20, Polysorbate 60, Sodium Hydroxide, Sodium Metabisulfite, Isomalt, Disodium EDTA, Chlorphenesin, Benzyl Alcohol, Benzoic Acid, Sorbic Acid, Fragrance/Parfum, Geraniol, Hexyl Cinnamal, Alpha Isomethyl Ionone, Amyl Cinnamal, Linalool, Butylphenyl Methylpropional, Citronellol, Limonene.

    Visit our Full Ingredient List and Definition page to learn more about our ingredients. 


    Parabens, sulfates, mineral oil, silicones, propylene glycol, ethoxylated ingredients (PEGs), phenoxyethanol, gluten, dyes, phthalates, genetically-modified organisms (GMOs), formaldehyde and formaldehyde releasers, soy, nuts, animal testing, animal byproducts.

  • Learn more about our New! Advanced Retinol Serum.


  • Our Recent Press:

    Spa Inc13 Retinols That Rival Their Rx CounterpartsThink Dirty’s 12 Days of Gifting: Day 1 — The Workaholic

Clean formulations, clinical results. Dermatologist-formulated and tested. Paraben-free, gluten-free, cruelty-free and vegan.

Customer Reviews
4.7 Based on 19 Reviews
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Filter Reviews:
Rhonda H.
United States United States
  • What is your skin type? Normal
  • What is your skin condition? Normal
First Retinol User

I have seen a noticeable difference in my fine lines. In my mid-40’s & new to retinol so I followed the directions closely and experienced no flaking or redness. I apply twice a week. The scent is amazing!

Patricia P.
United States United States
  • What is your skin type? Normal
  • What is your skin condition? Normal
Great so far

Only used once but it was a good experience. Face was warm but not bad. Flushed in the morning but gone by the afternoon. Light scent that I could handle. Unscented would be better. Fingers crossed I can keep using it. Looks very promising.

andrea h.
United States United States
Gentlest Retinol treatment

I was originally reluctant to use as I have reacted badly to other retinol treatments. I am amazed how gentle the serum is.

Catherine D.
United States United States
Loving it so far

As an ardent (daily) exfoliator who has never used retinol I thought it best to back off on the exfoliation and slowly add the retinol into my skincare regime. So far so good! I have gradually increased usage to twice a week with no breakouts, flakiness, scaling or irritation so I'd call that a good response. This week I plan to increase to three times per week and I hope for the best. I'll report back soon but as a first retinol experience I am more than pleased. If you are hesitant to try retinol I'd say 'give this product a go'!

Isabelle G.
Canada Canada

Great product! A light texture, non-greasy with a delicate odor. Good for sensitive skin.

Catherine H.
United States United States
Best ever

This retinol is stellar! I started using it October 2019 and it’s amazing the difference in my skin!! I will not live without this product. Thank You Alchimie

Shery E.
United States United States
Retinol Serum

I wasn't expecting much from a retinol product with 0.75% retinol, as I have previously used 1% and 5% products. I have been so pleasantly surprised with this product as I can see the results, but have had no side effects overall. I would definitely recommend this retinol serum to anyone who has sensitive skin, and didn't want to risk side effects from retinol, but wanted the benefit.

Alissa H.
United States United States
Love it!

Really gentle yet effective.

United States United States
Advanced retinol serum

So far this has been great. my skin definitely broke out in the beginning as my skin was purging all the toxins but after 2 weeks the acne cleared up and my skin is now extremely clear. Excited to see how it will continue to improve

Catherine H.
United States United States
Best Retinol on the Market

If you are shopping for a retinol, look no further. Alchimie's 48-hour time release formula delivers a punch without irritating my skin. It's quite astonishing. The consistency and scent are great ... but can we talk about the results? When your aesthetician notices a difference in the firmness of your skin and the reduction of wrinkles, you know you landed on a stellar product!